Growth Regulation Hormone Assignment Example | Topics and Well Written Essays - 3000 words

Growth Regulation Hormone - Assignment Example The specific receptor of GH (GHR) is a 638-aminoacid protein, a receptor of the extrinsic tyrosine kinase group encoded on chromosome 5. It consists of an extracellular part to bind GH, a trans-membrane sequence and a cytoplasmic part. The GHR-JAK2(Janus tyrosine kinase) activation of signalling molecules can result in different cellular responses, some of which involve the activation of transcription from target genes, while others involve metabolic changes. Introduction Growth Regulatory Hormones are those hormones secreted under the control of the endocrine system. They include the Growth Hormone, somatostatins, somatomedins (IGFs) and others which are important in regulating the various aspects of growth in the body. The most important of these is the Growth Hormone (GH) which will be studied in details in this review. It is secreted from the anterior pituitary under the command of Growth Hormone Releasing Hormone of the hypothalamus and is regulated and modulated by various othe r hormones and exert its growth promoting actions by activating various signalling pathways and cross talk mechanisms which will be elucidated in this review. In this review we will specifically focus on GH and its relation to other hormones and molecular mechanisms regulating growth in the body.[1,2,3,] Growth Regulatory Hormones: A Preview Regulation of body growth is under the control of the endocrine system, which is a coordinated system of hormones secreted by special glands in the body. These hormones regulate every aspect of growth, metabolism and sexual functions also. The chief hormones regulating body growth are: Growth hormone (GH) GH, also called the somatotrophic hormone is the key regulator of growth in the body. They increase the synthesis of various proteins and elongate the bones at the growth plates. In childhood and adolescence it causes increase in height. There are other roles also like increasing the muscle mass, calcium retention in the bones and stimulating t he immune system. Growth Hormone Releasing Hormone (GHRH) The endocrine system is finely regulated for secretion of various hormones by feedback mechanisms. Thus GHRH is secreted from the hypothalamus controls the secretion of GH secretion from the pituitary gland.This means when GH pulse is low, increased GHRH secretion cause pineal gland to revive the pulse of GH and when GH pulse is high GHRH secretion decreases. Somatostatin Also called the Growth Hormone Inhibiting Hormone (GHIH) it decreases the amount of GH in the body. It is also secreted from the hypothalamus and tightly controls the release of GH in association with GHRH. Estrogen and Progesterone These hormones start the growth spurt seen in at the beginning of puberty by activating GH. They also functions to seal off the growth plates when a person reaches his adult height. These hormones start the growth spurt seen in at the beginning of puberty by activating growth hormone. They also function to seal off the growth pla tes when a person reaches his adult height. [1,2,3,4] Background of Growth Hormone Secretion Growth Hormone is secreted in a pulsatile manner from the anterior pituitary gland. It is a peptide hormone consisting of 191 amino acid residues and contains 2disulphide bonds. The 20kda and 22kda isoforms are the important ones. There are 5

Book Review Essay Example | Topics and Well Written Essays - 1000 words - 5

Book Review - Essay Example These documents are tangible proof of the manner in which governments and titans of the industry have harmed their own people. What is most shocking is the tendency of investigating agencies to later help in the cover up operations mounted by these industrial giants and the so-called protectors of the citizens of the nation. These accounts of governmental apathy and disregard for innocents raises the troubling question of how safe are we, the populace of a nation. In this summary, we shall be discussing this hand in glove attitude of people in power, who treat common individuals as guinea pigs in their quest for control over the world. Edwin Black’s IBM and the Holocaust is a painstaking episode delving into the convergence of technology and the extermination of Jews in Nazi Germany between 1935 and 1945. It is a powerful documentation of how Thomas J. Watson’s (Chief of IBM at the time) greed and his desire to monopolize the emerging market of technological possibilities led him to make covert deals with Hitler’s government. Hitler was not the first man to hate the Jews, but his terrifying objectives of wiping out Jews from Europe was aided by the â€Å"solution providers† at IBM. The IBM Hollerith D-11, card sorting machine, which identified the Jews during the 1933 census, in a way sealed their fates forever. Edwin Black lays the blame for the condition of Jews as much on Hitler as the card machines provided to the Third Reich by Thomas J Watson’s company. These machines helped in cross indexing government, church and communal records. Edwin Black juxtaposed the movement of ma chines from one Nazi occupied territory to another and uncovered that it was these machines, using punch cards, all provided by IBM, which helped in the systematic slaughter to Jews. These lists can be termed as glaring instances of corporate misconduct, because the greed of one company fed the vicious ambitions of one individual,